Retinal thickness and volume measured with enhanced depth imaging optical coherence tomography

Area of Science:

• Ophthalmology
• Medical Imaging
• Retinal Imaging

Background:

• Spectral-domain optical coherence tomography (OCT) is crucial for retinal imaging.
• Enhanced depth imaging (EDI) is a newer OCT protocol.
• Comparing EDI OCT with conventional OCT is important for clinical application.

Purpose of the Study:

• To compare retinal thickness and volume measurements obtained via EDI OCT and conventional OCT.
• To assess the agreement between these two OCT methods.

Main Methods:

• Retrospective analysis of 20 healthy subjects and 35 patients with chorioretinal diseases.
• Spectral-domain OCT performed using both conventional and EDI raster scan protocols.
• Measurement of retinal thickness and volume in 9 Early Treatment Diabetic Retinopathy Study subfields; statistical analysis using intraclass correlation coefficients and Bland-Altman plots.

Main Results:

• High intraclass correlation coefficients (0.861–0.995) between conventional and EDI OCT for retinal thickness and volume.
• Narrow 95% limits of agreement for central subfield measurements (-14.52 to 12.88 μm for thickness, -0.014 to 0.013 mm³ for volume).
• Statistically insignificant differences in segmentation error rates between protocols, except in cases of reticular pseudodrusen.

Conclusions:

• EDI OCT raster scan demonstrates high agreement with conventional OCT for retinal and choroidal measurements.
• EDI OCT is a reliable method for evaluating both retina and choroid in healthy individuals and patients with certain chorioretinal conditions.
• The findings support the clinical utility of EDI OCT in ophthalmology.