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Related Experiment Video

Updated: May 10, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Obesity, growth hormone and exercise.

Gwendolyn A Thomas¹, William J Kraemer, Brett A Comstock

¹School of Nursing, Yale University, New Haven, CT, USA.

Sports Medicine (Auckland, N.Z.)

|July 2, 2013

Summary

Exercise, particularly resistance training, can stimulate growth hormone (GH) release in obese individuals. Optimizing exercise intensity and duration may offer a therapeutic target for improving body composition in obesity.

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A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

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Published on: June 3, 2016

Area of Science:

Endocrinology
Exercise Physiology
Obesity Research

Background:

Obesity is believed to disrupt the regulation of growth hormone (GH) secretion.
Pulsatile GH release is crucial for modulating fuel metabolism and reducing fat mass.

Purpose of the Study:

To review factors affecting GH secretion, how obesity alters it, and the role of exercise in stimulating GH release.
To explore exercise as a potential therapeutic target for endogenous GH release in obese individuals.

Main Methods:

Literature review of factors influencing GH secretion.
Analysis of studies investigating exercise (aerobic and resistance) as a stimulus for GH release.
Focus on exercise intensity and duration parameters.

Main Results:

Both aerobic and resistance exercise can stimulate pulsatile GH release in healthy individuals.
Obesity may alter normal GH secretion patterns.
Resistance exercise, with specific variables, shows potential for stimulating endogenous GH in obese populations.

Conclusions:

Increasing pulsatile GH response may be a therapeutic target for obesity.
Resistance exercise may be a viable strategy for releasing endogenous GH in obese individuals.
Further research is needed on molecular GH variants and optimal exercise parameters.