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Updated: May 10, 2026
08:12
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
[Relationship between microRNA-155 and hematological malignancies].
Hua Xue1, Luo-Ming Hua, Jian-Min Luo
1Department of Hematology, Affiliated Hospital of Hebei Universtity, Hebei Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|July 3, 2013
Summary
MicroRNA-155 (miR-155) is an oncomir crucial in hematopoietic malignancies. Down-regulating miR-155 shows promise as a targeted therapy for these cancers.
Area of Science:
- Molecular biology
- Genetics
- Oncology
Context:
- MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
- miR-155 is highly expressed in hematopoietic cells and implicated in various cellular processes.
- Emerging evidence links miR-155 to the pathogenesis of hematological malignancies.
Purpose:
- To review the current understanding of miR-155's role in hematopoietic malignancies.
- To explore miR-155 as a potential diagnostic and prognostic biomarker.
- To highlight miR-155 as a therapeutic target for hematological cancers.
Summary:
- miR-155 acts as an oncomir, promoting proliferation, inhibiting differentiation, and preventing apoptosis in hematopoietic cells.
- Its dysregulation is observed in malignant lymphoma, acute myeloid leukemia, and myelodysplastic syndromes.
- miR-155 influences key cell signaling pathways involved in cancer development.
Impact:
- miR-155 serves as a potential biomarker for diagnosing and predicting outcomes in hematological malignancies.
- Targeting miR-155 with antisense oligonucleotides offers a novel therapeutic strategy.
- This approach could complement conventional cytotoxic therapies for improved cancer treatment.
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