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Interleukin-13 +1923C/T polymorphism is associated with asthma risk: a meta-analysis
1Department of Intensive Care Medicine, No. 411 Hospital of PLA, Shanghai 200080, China.
Biomed Research International
|July 11, 2013
Summary
The interleukin-13 (IL-13) +1923C/T genetic variation is linked to an increased risk of asthma. This meta-analysis confirms IL-13 +1923C/T polymorphism as a significant asthma risk factor.
Area of Science:
- Genetics
- Immunology
- Respiratory Medicine
Background:
- Asthma is a complex respiratory disease with a significant genetic component.
- The role of specific genetic polymorphisms, such as in interleukin-13 (IL-13), in asthma susceptibility remains debated.
Purpose of the Study:
- To conduct a meta-analysis to definitively assess the association between the IL-13 +1923C/T polymorphism (rs1295686) and asthma risk.
- To evaluate the consistency of this association across different ethnicities and study qualities.
Main Methods:
- A systematic literature search was performed across major databases (PubMed, EMBASE, CNKI) up to October 16, 2012.
- Ten studies involving 13,698 cases and 38,209 controls were included in the meta-analysis.
- Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated, and subgroup, sensitivity, and cumulative analyses were conducted.
Main Results:
- A significant association was found between the IL-13 +1923C/T polymorphism and asthma risk under a codominant model.
- This association persisted in stratified analyses by ethnicity (Asians and Caucasians) and in high-quality studies.
- Sensitivity and cumulative analyses supported the robustness of the findings, with no evidence of publication bias.
Conclusions:
- The IL-13 +1923C/T polymorphism (rs1295686) is confirmed as a significant risk factor for asthma.
- This genetic variation contributes to asthma susceptibility across different ethnic groups and is reliably detected in high-quality research.
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