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Updated: May 9, 2026
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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Metabolomics application in maternal-fetal medicine
Vassilios Fanos1, Luigi Atzori, Karina Makarenko
1NICU, Puericulture Institute and Neonatal Section, AOU and University of Cagliari, 09124 Cagliari, Italy.
Biomed Research International
|July 11, 2013
Summary
Metabolomics, the study of metabolites, is emerging in maternal-fetal medicine. It shows strong links between biomarkers in maternal and fetal tissues and various pregnancy complications and neonatal outcomes.
Area of Science:
- Maternal-Fetal Medicine
- Metabolomics
- Biomarker Discovery
Background:
- Metabolomics in pregnancy is an emerging field with growing interest.
- Investigating the metabolome of normal and complicated pregnancies is crucial for understanding neonatal outcomes.
Purpose of the Study:
- To review and synthesize existing research on metabolomics in obstetrics.
- To highlight the clinical potential of metabolomics for diagnosing and managing pregnancy complications.
Main Methods:
- Analysis of published original data.
- Interrogation of various biological tissues including amniotic fluid, blood, plasma, cord blood, placenta, urine, and vaginal secretions.
Main Results:
- Strong correlations identified between specific biomarkers and adverse pregnancy outcomes.
- Key outcomes linked to metabolomic profiles include fetal malformations, preterm delivery, gestational diabetes mellitus, preeclampsia, and hypoxic-ischemic encephalopathy.
Conclusions:
- Metabolomics holds significant promise for advancing maternal-fetal medicine.
- Future applications include improved diagnostics and management strategies for pregnancy-related conditions.
