lncRNome: a comprehensive knowledgebase of human long noncoding RNAs.

Area of Science:

• Genomics
• Molecular Biology
• Bioinformatics

Background:

• High-throughput genome-scale technologies have identified numerous transcriptionally active genomic regions.
• Recent studies have annotated a vast array of noncoding transcripts, with long noncoding RNAs (lncRNAs) constituting a significant portion.
• lncRNAs are implicated in diverse biological functions, expanding our understanding of the transcriptome.

Purpose of the Study:

• To address the gap in stable annotation, cross-referencing, and biologically relevant information for lncRNAs.
• To establish lncRNome as a comprehensive knowledgebase integrating diverse biologically significant data for lncRNAs.
• To provide researchers with a centralized and extensive resource for studying lncRNAs.

Main Methods:

• Genome-wide studies to identify and annotate noncoding transcripts.
• Integration of annotations for various classes of noncoding transcripts, including lncRNAs.
• Development of a comprehensive knowledgebase (lncRNome) for lncRNA data.

Main Results:

• Over 18,000 transcripts are currently annotated as lncRNAs.
• lncRNAs encompass previously identified noncoding transcript classes like large intergenic noncoding RNA, antisense RNA, and processed pseudogenes.
• The lncRNome database has been established as a large and comprehensive resource for lncRNA information.

Conclusions:

• The lncRNome database effectively bridges the gap in lncRNA resources by providing integrated, stable, and biologically relevant information.
• This resource facilitates deeper research into the functions and roles of the rapidly expanding repertoire of lncRNAs.
• lncRNome represents a significant advancement in the field, offering one of the most extensive collections of lncRNA data available.