Related Experiment Video
Updated: May 9, 2026
Gramicidin-based Fluorescence Assay; for Determining Small Molecules Potential for Modifying Lipid Bilayer Properties
Published on: October 13, 2010
Aza-Michael access to fluoroalkylidene analogues of biomolecules
Anaïs Prunier1, Charlène Calata, Julien Legros
1Laboratoire de Chimie Moléculaire et Thioorganique, CNRS UMR 6507 & FR3038, Normandie Université, UNICAEN, ENSICAEN, 6 Boulevard du Maréchal Juin, 14050 Caen Cedex, France.
Abstract:
The synthesis of fluoroaminosulfones derived from piperidine and nucleic bases followed by the study of their chemical behavior in the modified Julia reaction are described. The resulting aminosulfones open a straightforward access to a series of new fluorinated biomolecules including a potent DPP-II inhibitor and acyclonucleoside analogues as potential enzyme inhibitors.
