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Oral premalignancy: the roles of early detection and chemoprevention
Jean-Philippe Foy1, Chloé Bertolus, William N William
1Department of Maxillofacial Surgery, Pitié-Salpêtrière Hospital, 47-83 boulevard de l' Hôpital, Paris 75013, France.
Abstract:
Premalignancy and chemoprevention studies in head and neck cancer typically focus on the oral cavity. Avoiding or cessation of alcohol and smoking, early detection of potentially malignant disorders or cancer, and early detection of recurrent and/or second primary tumor form the basis of prevention of oral cancer. Analysis of tissue prospectively collected in evaluation of retinoids for chemoprevention trials allowed identification of molecular biomarkers of risk to develop oral cancer, loss of heterozygosity being the most validated one. Improving risk assessment and identification of new targets for chemoprevention represent the main challenges in this field.
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