Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Bones of the Upper Limb: Radius01:09

Bones of the Upper Limb: Radius

The radius is longer of the two bones that make up the human antebrachium or forearm. At the proximal end, the radius articulates with the capitulum of the humerus and the radial notch of the ulna to form the elbow joint. At the distal end, the radius articulates with the ulna via the ulnar notch, forming the distal radioulnar joint. Distally, the radius also attaches to the carpal wrist bones (scaphoid and lunate) to form the radiocarpal joint.
The radius has a nail-shaped head, and a short...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dental manifestations of rare skeletal disorders: Diagnosis and treatment for the oral health care provider.

Journal of the American Dental Association (1939)·2026
Same author

Effects of comorbid chronic kidney disease on late-onset hypophosphatasia mice under treatment with asfotase alfa.

JBMR plus·2026
Same author

TNAP and PHOSPHO1 function synergistically to afford critical control over the mineralisation of the postnatal murine skeleton.

bioRxiv : the preprint server for biology·2026
Same author

Mineral-targeted alkaline phosphatase improves bone graft-mediated alveolar bone defect healing in mice.

Journal of periodontology·2026
Same author

<i>Alpl</i> ablation in dental epithelium disrupts ameloblasts and incisor enamel mineralization in male mice.

JBMR plus·2026
Same author

In Vivo Comparison of Resin-Modified and Pure Calcium-Silicate Cements for Direct Pulp Capping.

Applied sciences (Basel, Switzerland)·2025
Same journal

Sex Hormones & Exercise in the Musculoskeletal System: From Signaling to Structure and Function.

Endocrine reviews·2026
Same journal

DAX-1 in sex determination and gonadal development: revisiting the anti-testis hypothesis.

Endocrine reviews·2026
Same journal

Regulators of Appetite in Mammals - Old and New players.

Endocrine reviews·2026
Same journal

Endometriosis-associated Pain: Mechanism, Neuroimmune Signature, and Translational Precision Strategies.

Endocrine reviews·2026
Same journal

Nuclear Receptors Shape Sepsis Pathophysiology.

Endocrine reviews·2026
Same journal

Beyond aldosterone and renin: emerging biomarkers for diagnosing and subtyping primary aldosteronism.

Endocrine reviews·2026
See all related articles

Related Experiment Video

Updated: May 8, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
07:26

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

The rachitic tooth.

Brian L Foster1, Francisco H Nociti, Martha J Somerman

  • 1National Institute for Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892.

Endocrine Reviews
|August 14, 2013
PubMed
Summary
This summary is machine-generated.

Rickets, traditionally linked to vitamin D deficiency, also impacts tooth mineralization due to genetic factors affecting calcium and phosphate regulation. This review explores the dental defects associated with various forms of rickets.

More Related Videos

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models
06:16

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models

Published on: April 26, 2024

Related Experiment Videos

Last Updated: May 8, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
07:26

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models
06:16

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models

Published on: April 26, 2024

Area of Science:

  • Mineralization disorders
  • Developmental biology
  • Endocrinology

Background:

  • Teeth, like bone, are mineralized tissues susceptible to developmental failures.
  • Rickets, historically vitamin D deficiency, now encompasses genetic disorders of phosphate and calcium regulation.
  • Defective dentition is a common comorbidity in individuals with rickets.

Purpose of the Study:

  • To review the dental manifestations of rickets.
  • To explore the etiologies of hereditary rickets and their impact on tooth and bone mineralization.
  • To discuss the mechanisms underlying dental pathologies in rickets.

Main Methods:

  • Review of human pathologies associated with rickets.
  • Analysis of transgenic mouse models to understand tooth defect mechanisms.
  • Integration of systemic and local mineralization regulation factors.

Main Results:

  • Rickets can result from genetic defects in phosphate and calcium regulation, including fibroblast growth factor 23 and dentin matrix protein 1.
  • Loss of tissue nonspecific alkaline phosphatase activity leads to mineralization defects.
  • Tooth defects in rickets may or may not mirror bone defects, with insights gained from mouse models.

Conclusions:

  • Hereditary rickets presents diverse bone and tooth mineralization disorders.
  • Understanding the mechanisms of rickets is crucial for addressing associated dental pathologies.
  • Transgenic models provide valuable insights into the pathogenesis of rachitic tooth defects.