Antibody to lymphocytic choriomeningitis virus in children with congenital hydrocephalus

Antibody to lymphocytic choriomeningitis (LCM) virus was found by the indirect immunofluorescence (IF) technique in high titres in 9 out of 28 children with congenital hydrocephalus and in moderate titres in 6 mothers of these seropositive children. It is suggested that LCM virus or a closely related virus infecting the foetus in utero may play a role in the aetiopathogenesis of some cases of congenital hydrocephalus.