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Updated: May 8, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation therapy: posterior segment complications.

Stefan Seregard¹, David E Pelayes, Arun D Singh

¹St Eriks Eye Hospital, Karoliniska Institutet, Stockholm, Sweden.

Developments in Ophthalmology

|August 31, 2013

Summary

This summary is machine-generated.

Therapeutic radiation for eye conditions can cause complications like radiation retinopathy and optic neuropathy, potentially leading to vision loss. Minimizing radiation dose to healthy eye tissues is crucial for preventing these adverse effects.

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Area of Science:

Ophthalmology
Radiation Oncology
Medical Physics

Background:

Therapeutic radiation is frequently used for posterior segment eye tumors, benign neoplasms, and non-neoplastic conditions like age-related macular degeneration.
Orbital diseases and extraocular malignancies treated with radiotherapy can also affect the eye, including the optic nerve and posterior segment.

Purpose of the Study:

To review the complications associated with therapeutic radiation to the posterior segment of the eye.
To discuss the factors influencing the development of radiation-induced ocular damage.
To highlight the current challenges in managing these complications.

Main Methods:

Literature review of radiation-induced ocular complications.
Analysis of factors contributing to radiation damage, including dose, volume, and fractionation.
Discussion of common and less frequent complications and their clinical impact.

Main Results:

Radiation retinopathy and optic neuropathy are the most common complications, potentially causing blindness.
Radiation scleral necrosis is less frequent but can necessitate eye enucleation.
Complication rates are primarily linked to the radiation dose delivered to the posterior segment, irradiated tissue volume, and fractionation schedules.

Conclusions:

Effective management strategies for radiation-induced ocular damage are still under investigation and remain controversial.
Preventing radiation complications by minimizing dose to normal tissues is the most effective approach.
Further research is needed to establish proven treatments for radiation-induced ocular damage.