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Updated: May 8, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Gender differences in cardiac left ventricular mass and function: Clinical and experimental observations
Eduardo Manuel Escudero1, Alejandro Orlowski, Alejandro Díaz
1Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, CONICET, La Plata, Argentina. emescu@gmail.com.
Aging impacts left ventricular mass (LVM) and function (LVF) differently in males and females. While male rats show increased LVM with aging, human men exhibit greater LVM but reduced LVF compared to women.
Area of Science:
- Cardiovascular Physiology
- Comparative Biology
- Aging Research
Background:
- Aging affects cardiac structure and function.
- Gender differences in cardiovascular aging are not fully understood.
- Left ventricular mass (LVM) and left ventricular function (LVF) are key indicators of cardiac health.
Purpose of the Study:
- To investigate the gender-specific effects of aging on LVM and LVF in humans and rats.
- To compare cardiac remodeling and function between male and female aging models.
Main Methods:
- Echocardiography was used to assess LVM and LVF in humans and rats.
- Myocyte area and collagen volume fraction (CVF) were analyzed in rat cardiac tissue.
- LVM index (LVMI) was calculated for comparative analysis.
Main Results:
- In adult rats, males showed significantly higher LVMI and myocyte area than females, with similar CVF.
- Human men had greater LVMI than women.
- Human women exhibited superior LVF compared to men, despite similar LVM in children.
Conclusions:
- Aging influences LVM and LVF in a gender-dependent manner in both rats and humans.
- Increased cardiac mass in male rats appears to be a physiological adaptation.
- The dissociation of increased cardiac mass and function in aging men suggests a potential adaptive disadvantage compared to women.
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