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Published on: April 5, 2017
Initial drug resistance pattern among pulmonary tuberculosis patients
Harshita Gupta1, Surya Kant, Amita Jain
1Department of Pulmonary Medicine, King George's Medical University, Lucknow, India.
The Indian Journal of Tuberculosis
|September 5, 2013
Summary
Drug-resistant tuberculosis (DRTB) is a growing concern. This study found a high prevalence of drug resistance and multi-drug resistance (MDR) among new pulmonary tuberculosis patients in India, highlighting the need for updated control strategies.
Area of Science:
- Public Health
- Infectious Diseases
- Microbiology
Background:
- Drug-resistant tuberculosis (DRTB) poses a significant threat to global public health, particularly in developing nations.
- Treatment outcomes for DRTB are often poor, exacerbating the challenge of disease control.
Purpose of the Study:
- To determine the initial drug resistance patterns in pulmonary tuberculosis patients.
- To assess drug susceptibility among patients registered under the Revised National Tuberculosis Control Programme.
Main Methods:
- A cross-sectional study was conducted in two urban Directly Observed Treatment Supervised (DOTS) centers in Lucknow District, Uttar Pradesh.
- Newly diagnosed sputum smear-positive pulmonary tuberculosis cases underwent culture and drug-susceptibility testing using the 1% proportion method on Lowenstein-Jensen medium.
Main Results:
- Of 185 patients, 170 (91.4%) had culture-positive isolates, with 169 (99.4%) identified as Mycobacterium tuberculosis.
- 21.3% of M. tuberculosis isolates exhibited resistance to at least one drug, with specific rates for single (5.9%), double (10.7%), triple (2.4%), and quadruple (2.4%) drug resistance.
- Multi-drug resistance (MDR-TB) was found in 4.7% of the isolates.
Conclusions:
- The study reveals a high incidence of drug resistance and MDR-TB among new sputum smear-positive pulmonary tuberculosis patients.
- Continuous surveillance of drug resistance profiles is crucial for developing effective treatment strategies within national tuberculosis control programs.
- Addressing the threat of MDR-TB requires updated interventions to improve patient outcomes and public health.
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