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Updated: May 8, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
[Adjuvant chemotherapy for patients with rectal cancer]
Camilla Qvortrup1, John Pløen Mortensen, Per Pfeiffer
1Onkologisk Afdeling R, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C. camilla.qvortrup@ouh.regionsyddanmark.dk.
Abstract:
A new Cochrane meta-analysis evaluated adjuvant chemotherapy (5-fluorouracil (5FU)-based, not modern combination chemotherapy) in almost 10,000 patients with rectal cancer and showed a 17% reduction in mortality corresponding well to the efficacy observed in recent studies, which reported a reduction in mortality just about 20%. The authors recommend adjuvant chemotherapy which is in accordance with the Danish national guidelines where 5-FU-based chemotherapy is recommended for stage III and high-risk stage II rectal cancer.
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