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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Targeting the p53 pathway

Vita M Golubovskaya1, William G Cance

  • 1Department of Surgical Oncology, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14127, USA; CureFAKtor Pharmaceuticals, 14 Rock Dove Lane, Orchard Park, Buffalo, NY 1427, USA.

Surgical Oncology Clinics of North America
|September 10, 2013
PubMed

Insights

This review covers targeting the p53 pathway in cancer, focusing on signaling pathways and therapeutic strategies like p53 reactivation and targeting p53-focal adhesion kinase interactions for broad cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • The p53 protein is a critical tumor suppressor.
  • Dysregulation of the p53 pathway is common in many cancers.
  • The Mdm-2 protein regulates p53 stability and function.

Purpose of the Study:

  • To review translational studies targeting the p53 pathway in cancer.
  • To discuss current therapeutic strategies for p53 reactivation.
  • To explore targeting the interaction between p53 and focal adhesion kinase (FAK).

Main Methods:

  • Literature review of translational studies.
  • Summary of p53 and Mdm-2 signaling pathway functions.
  • Analysis of therapeutic approaches targeting p53.

Main Results:

  • The p53 pathway is a viable target for cancer therapy.
  • Reactivation of p53 function shows therapeutic potential.
  • Direct interaction between p53 and FAK in cancer cells has been identified.

Conclusions:

  • Targeting the p53 pathway offers a broad approach to cancer treatment.
  • Developing therapies that reactivate p53 is a key strategy.
  • Inhibiting the p53-FAK interaction presents a novel therapeutic avenue.
Keywords:
ApoptosisFAKMdm-2Survivalp53

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