[Fibronectin and insulin-like growth factor-1 in pathogenesis of open-angle and pseudoexfoliative glaucoma]

The aim of the present investigation was to study the role of fibronectin and insulin-like growth factor-1 (IGF-1) in pathogenesis of primary open-angle and pseudoexfoliative glaucoma. Immune enzyme analysis was performed on aqueous humour of 480 patients with complicated cataracts on the background of primary open-angle and pseudoexfoliative glaucoma. The aqueous humour of patients with senile cataracts was used as control. The content of fibronectin and IGF-1 in aqueous humour was determined using appropriate kits (DRG-International Inc., USA) in the absorbance wavelength range 420-450 nm. The obtained results were analyzed using Student's criteria and application of SPSS-13/80. Relatively high levels of fibronectin and IGF-1 were recorded in aqueous humour of patients with complicated cataracts (cataracts on the background of open-angle and pseudoexfoliative glaucoma), as compared to indices of both cytokines in the aqueous humour of control group patients. In mechanisms of eye drainage function impairment and intraocular pressure increase an important role belongs to in situ (i.e. in the eye membranes) produced fibronectin and IGF-1.