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Profiling human Src homology 2 (SH2) domain proteins and ligand discovery using a peptide-hybrid small molecule

Jiaqi Fu1, Zhenkun Na, Mahesh Uttamchandani

  • 1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543. chmyaosq@nus.edu.sg.

Chemical Communications (Cambridge, England)
|September 12, 2013
PubMed

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Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...