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Biodegradable salicylate-based poly(anhydride-ester) microspheres for controlled insulin delivery
Roberto Delgado-Rivera1, Roselin Rosario-Meléndez, Weiling Yu
1Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, 08854.
Journal of Biomedical Materials Research. Part A
|September 13, 2013
Summary
This study developed salicylate-based poly(anhydride-esters) (PAEs) microspheres for dual drug delivery. These microspheres successfully encapsulated and released bioactive insulin and anti-inflammatory salicylic acid simultaneously.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Salicylate-based poly(anhydride-esters) (PAEs) offer controlled release of incorporated salicylic acid (SA) via polymer hydrolysis.
- Developing effective carriers for simultaneous delivery of multiple therapeutic agents is a key challenge in pharmaceutical research.
Purpose of the Study:
- To formulate and characterize salicylate-based PAE microspheres for the co-delivery of insulin and salicylic acid (SA).
- To evaluate the in vitro release kinetics, bioactivity of insulin, and anti-inflammatory potential of SA from the formulated microspheres.
Main Methods:
- Formulation of polymer microspheres using a water/oil/water double-emulsion solvent evaporation technique.
- In vitro release studies of insulin and SA over 15 days.
- Assessment of insulin secondary structure and bioactivity.
- Evaluation of the anti-inflammatory activity of released SA.
Main Results:
- Microspheres exhibited smooth surfaces, high protein encapsulation efficiency, and low emulsifier content.
- Sustained in vitro release of insulin for 15 days without aggregation or structural changes.
- Released insulin retained its bioactivity.
- Concomitant release of SA with polymer degradation, demonstrating anti-inflammatory activity.
Conclusions:
- Salicylate-based PAE microspheres are effective carriers for simultaneous delivery of insulin and SA.
- Both encapsulated agents retain their bioactivity and therapeutic potential after processing and release.
- This dual-delivery system holds promise for managing conditions requiring both insulin and anti-inflammatory therapy.
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