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Related Concept Videos

Fixation and Sectioning01:03

Fixation and Sectioning

Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...

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Related Experiment Video

Updated: May 7, 2026

Optical Clearing and Imaging of Immunolabeled Kidney Tissue
06:18

Optical Clearing and Imaging of Immunolabeled Kidney Tissue

Published on: July 22, 2019

Tissue clearing for optical anatomy.

Dmytro A Yushchenko1, Carsten Schultz

  • 1Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany).

Angewandte Chemie (International Ed. in English)
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Achieving transparency in thick biological tissues is challenging due to light scattering. The CLARITY method offers a new approach for detailed optical imaging of tissues and organs with cellular resolution.

Keywords:
fluorescence imaginglight scatteringmicroscopytissue clearing

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Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
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Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

Related Experiment Videos

Last Updated: May 7, 2026

Optical Clearing and Imaging of Immunolabeled Kidney Tissue
06:18

Optical Clearing and Imaging of Immunolabeled Kidney Tissue

Published on: July 22, 2019

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
10:28

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

Area of Science:

  • Biomedical Engineering
  • Optical Imaging
  • Neuroscience

Background:

  • Detailed optical imaging of complex biological structures is hindered by light scattering in tissues.
  • Existing methods struggle to provide cellular resolution in thick biological samples.

Purpose of the Study:

  • To introduce and evaluate CLARITY, a novel tissue clearing technique.
  • To overcome the limitations of light scattering for enhanced biological imaging.

Main Methods:

  • Development and application of the CLARITY tissue clearing process.
  • Utilizing advanced optical imaging techniques on cleared tissues.

Main Results:

  • CLARITY enables deep optical penetration into thick biological tissues.
  • The technique preserves cellular structures, allowing for high-resolution imaging.
  • Anatomical visualization of entire organs with cellular detail is achieved.

Conclusions:

  • CLARITY significantly advances the field of biological imaging by providing unprecedented transparency.
  • This method facilitates detailed anatomical and cellular studies of complex biological entities.