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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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CDK8 as the STAT1 serine 727 kinase?

Julia Staab1, Christoph Herrmann-Lingen, Thomas Meyer

  • 1Department of Psychosomatic Medicine and Psychotherapy; University of Göttingen; Göttingen, Germany.

JAK-STAT
|September 27, 2013
PubMed
Summary

Cyclin-dependent kinase 8 (CDK8) phosphorylates STAT1 serine 727 upon interferon-gamma (IFNγ) stimulation. This CDK8 module links STAT1 serine phosphorylation to gene transcription.

Keywords:
gene expressioninterferon signalingkinase activityserine phosphorylationtranscriptional regulation

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