Microfluidic Paper-Based Analytical Devices (μPADs) and Micro Total Analysis Systems (μTAS): Development,...

Area of Science:

• Analytical Chemistry
• Biotechnology
• Materials Science

Background:

• Microfluidic paper-based analytical devices (µPADs) and micro total analysis systems (µTAS) are emerging analytical tools.
• They enable the analysis of complex biological samples, including macromolecules, cells, and pathogens.

Purpose of the Study:

• This review summarizes the development, fabrication, applications, and future trends of microfluidic devices.
• To highlight their potential in various diagnostic and analytical fields.

Main Methods:

• Review of existing literature on microfluidic paper-based analytical devices and micro total analysis systems.
• Analysis of fabrication techniques and application examples.

Main Results:

• µPADs and µTAS facilitate fluidic manipulations such as transportation, sorting, mixing, and separation within a single analytical run.
• These devices are utilized for neurotransmitter detection, cancer diagnosis, cell culture, drug discovery, and microorganism identification.

Conclusions:

• Microfluidic devices represent a significant advancement in rapid, cost-effective biochemical analysis.
• Continued research and development promise expanded applications in medical screening, forensic diagnostics, and beyond.