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Prostate specific antigen in cord blood
1Department of Biochemistry, Dr. RP Government Medical College, Kangra, Himachal Pradesh India.
Indian Journal of Clinical Biochemistry : IJCB
|October 2, 2013
Summary
Prostate specific antigen (PSA) levels in cord blood are higher in male infants, at later gestational ages, and after operative delivery. These findings suggest a role for PSA in fetal development and response to birth stress.
Area of Science:
- Reproductive Biology
- Endocrinology
- Biochemistry
Background:
- Prostate specific antigen (PSA) is present in fetal cord blood, influenced by placental hormones like progesterone and estradiol.
- PSA's proteolytic activity suggests a role in fetal growth by modulating growth factors and cytokines.
Purpose of the Study:
- To investigate the correlation between cord blood PSA levels and gestational age, delivery type, and fetal gender.
- To explore potential hormonal influences on cord blood PSA concentrations.
Main Methods:
- Analysis of 57 cord blood samples using a highly sensitive two-site immuno-radiometric assay for PSA.
- Correlation of PSA levels with clinical data including gestational age, delivery method (vaginal, operative), and infant gender.
Main Results:
- Mean cord blood PSA was 0.112 ± 0.027 ng/ml.
- Higher PSA levels were observed with increased gestational age, in male infants, and following operative delivery.
- All male samples showed detectable PSA, whereas 50% of female samples had levels below the detection limit.
Conclusions:
- Cord blood PSA levels are significantly influenced by fetal gender, gestational maturity, and delivery interventions.
- Elevated PSA in male infants may be linked to higher prenatal progesterone levels.
- Increased cord blood PSA after operative delivery suggests a stress-induced response.
