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Organization of the Brain

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...

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Related Experiment Video

Updated: May 7, 2026

Fabrication of an Expandable Brain Matrix Customizable Across Developmental Stages

Fabrication of an Expandable Brain Matrix Customizable Across Developmental Stages

Published on: February 20, 2026

Build-a-brain.

Stuart M Chambers¹, Jason Tchieu, Lorenz Studer

¹Center for Stem Cell Biology, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA; Developmental Biology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.

|October 8, 2013

Summary

This summary is machine-generated.

Scientists developed cerebral organoids from pluripotent stem cells (PSCs) to model human brain development. This breakthrough allows studying cellular interactions and neurological disorders like microcephaly.

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Last Updated: May 7, 2026

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Area of Science:

Neuroscience
Developmental Biology
Stem Cell Research

Background:

Understanding human brain development is hindered by challenges in modeling cellular interactions.
Previous methods lacked the complexity to replicate in vivo developmental processes.

Purpose of the Study:

To establish a novel method for modeling the developing human brain.
To create a system that recapitulates key aspects of human neurodevelopment.

Main Methods:

Utilized pluripotent stem cells (PSCs) to generate three-dimensional "cerebral organoids."
Cultured organoids to mimic the developmental timeline and cellular organization of the human brain.

Main Results:

Cerebral organoids exhibited regional segregation, mirroring distinct brain areas.
The model successfully replicated the cellular organization of the developing human brain.
The organoid system demonstrated the capacity to model microcephaly.

Conclusions:

Pluripotent stem cell-derived cerebral organoids provide a powerful platform for studying human brain development.
This model facilitates research into cellular interactions and neurological disease mechanisms.
The protocol offers a new avenue for investigating developmental disorders affecting the human brain.