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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

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Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
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Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

Minireview: applied structural bioinformatics in proteomics.

Yee Siew Choong1, Gee Jun Tye, Theam Soon Lim

  • 1Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia, yeesiew@usm.my.

The Protein Journal
|October 8, 2013
PubMed
Summary
This summary is machine-generated.

Computational technology is essential for predicting protein structures due to limited sequence similarity. Structural bioinformatics (SB) aids in understanding protein sequence-structure-function relationships, with applications in protein engineering.

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Area of Science:

  • Structural bioinformatics
  • Computational biology
  • Protein science

Background:

  • Limited sequence similarity between proteins and known structures necessitates advanced prediction methods.
  • Understanding the protein sequence-structure-function paradigm is crucial for biological research.

Purpose of the Study:

  • To explore the applications of structural bioinformatics in protein engineering.
  • To identify the limitations and future challenges of structural bioinformatics in this field.

Main Methods:

  • Review of structural bioinformatics applications.
  • Analysis of limitations and challenges in protein engineering.

Main Results:

  • Structural bioinformatics is integral to elucidating protein relationships.
  • Key applications and challenges in protein engineering were identified.

Conclusions:

  • Structural bioinformatics is indispensable for protein structure prediction and engineering.
  • Addressing current limitations is vital for future advancements in the field.