Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: a novel finding
Kahraman Cosansu, Huseyin Altug Cakmak, Baris Ikitimur
1Istanbul University, Cerrahpasa Medical Faculty, Department of Public Health. alpincan@yahoo.fr.
Kardiologia Polska
|October 22, 2013
Summary
Apelin levels correlate differently with cardiac biomarkers in acute coronary syndromes (ACS). While positively associated in non-ST elevation ACS, apelin shows a negative correlation in ST-elevation myocardial infarction (STEMI) patients.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Apelin is an endogenous peptide with known inotropic and vasodilatory effects.
- Its role in acute coronary syndromes (ACS) requires further elucidation.
Purpose of the Study:
- To investigate apelin's prognostic role in ACS.
- To assess correlations between apelin and established diagnostic/prognostic markers.
Main Methods:
- Plasma apelin-36 levels were measured in 76 ACS patients (35 STEMI, 41 NSTE-ACS).
- Correlations with ejection fraction (EF), hsCRP, CK, CK-MB, and troponin I were analyzed.
- Patients were followed for one year for cardiovascular outcomes.
Main Results:
- No significant association found between apelin and TIMI, GRACE, GENSINI scores, hsCRP, or EF.
- Apelin positively correlated with CK, CK-MB, and troponin I in NSTE-ACS.
- Apelin negatively correlated with these biomarkers in STEMI patients.
Conclusions:
- Apelin exhibits differential correlations with cardiac biomarkers in STEMI versus NSTE-ACS.
- The observed negative correlation in STEMI may relate to the larger myocardial infarction size in these patients.
Related Concept Videos
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
961
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
961
01:30Acute Coronary Syndrome III: Diagnostic Studies
502
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
502
01:30Acute Coronary Syndrome I: Introduction
2.1K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
2.1K
01:30Coronary Artery Disease III: Clinical Manifestations
632
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
632
01:26Coronary Artery Disease II: Pathophysiology
1.1K
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
01:29Angina III: Clinical Manifestations and Assessment
487
Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
487