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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
An evidence-based proposal for predicting organ failure in severe acute pancreatitis
Xin Wang1, Yaling Xu, Yuwen Qiao
1From the *Department of General Surgery, †Center for Pancreatic Disease, Division of Gastroenterology, Hepatology and Colorectal Disease, and ‡Department of Ultrasonography, the Fourth Center Hospital; §Radiological Department in General Hospital, ∥Center for Pancreatic Disease, Division of Gastroenterology, Hepatology and Colorectal disease, Department of Medicine, ¶Center of Evidence-Based Medicine, Department of Statistics and Epidemiology, College of Public Health, and #Department of Neuroendocrine and Metabolism Disease, the Metabolism Medicine Hospital, Tianjin Medical University; **Department of Hematology Medicine, and ††Center for Severe Pancreatic Disease, Division of Intensive Care Unit, the Fourth Center Hospital; ‡‡Center for Hematic Disease Laboratory, Tianjin Medical University, Tianjin; and §§Department of International Herald Leader, Xin Hua News Agency, Beijing, China.
Objectives:
Early, efficient, and accurate evaluation for organ failure is an important step for improving outcome in severe acute pancreatitis (SAP). We aim to develop a method that can early, efficiently, and accurately evaluate the in-hospital organ failure in patients with SAP.
Methods:
Using multivariate logistic regression analysis, the associative factors for in-hospital organ failure were evaluated retrospectively from conventional data obtained from 393 patients with SAP from 2000 to 2012. In classification and regression tree analysis, a new clinical scoring system was developed for the evaluation of in-hospital organ failure in SAP. We also compared the accuracy of our new scoring system with multiple organ dysfunction score and Acute Physiology and Chronic Health Examination II score by the receiver operating characteristic curve.
Results:
Laboratory results revealed serum calcium level greater than or equal to 1.84 mmol/L, serum creatinine level greater than or equal to 110 µmol/L, age greater than or equal to 72 years, activated partial thromboplastin time less than or equal to 30.95 seconds, and Balthazar computed tomography score greater than or equal to 7 (CCAAB) score system, each contributed 1 point for the prediction of organ failure. The area under the curve of the CCAAB score system was similar to multiple organ dysfunction scores and Acute Physiology and Chronic Health Examination II scores.
Conclusions:
The new scoring system CCAAB is an efficient and accurate method for the early evaluation of patients with SAP for in-hospital organ failure.
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Acute Pancreatitis II: Clinical Manifestations and Management
Acute Pancreatitis II: Pathophysiology
Acute Pancreatitis I: Introduction
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis II: Collaborative Care
Assessment:
Chronic Pancreatitis I: Introduction

