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Updated: May 6, 2026

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Published on: September 14, 2018
Concise review: harmonies played by microRNAs in cell fate reprogramming
Sharif Moradi1, Sassan Asgari, Hossein Baharvand
1Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran; Department of Developmental Biology, University of Science and Culture, ACECR, Tehran, Iran.
MicroRNAs (miRNAs) are key regulators in gene regulatory networks (GRNs) and are emerging as powerful tools for cell reprogramming. They offer new avenues for regenerative medicine and understanding cellular plasticity.
Area of Science:
- Cell Biology
- Molecular Biology
- Regenerative Medicine
Background:
- Somatic cell reprogramming involves altering cell fates through defined factors.
- Gene regulatory networks (GRNs) govern differentiated cell states and exhibit plasticity.
- MicroRNAs (miRNAs) are integral components of GRNs, regulating gene expression.
Purpose of the Study:
- To review the role of miRNAs in somatic cell reprogramming.
- To highlight miRNAs as a novel reprogramming toolbox.
- To discuss the potential of miRNAs in regenerative medicine and future research.
Main Methods:
- Literature review of landmark studies on miRNAs in cell reprogramming.
- Analysis of miRNA functions in induced pluripotency and direct lineage reprogramming.
- Discussion of implications for regenerative medicine and the evolution of reprogramming technology.
Main Results:
- MicroRNAs (miRNAs) significantly modulate cellular processes, including reprogramming.
- miRNAs offer powerful tools for interrogating reprogramming mechanisms.
- miRNAs hold promise for generating safe cell sources for regenerative medicine.
Conclusions:
- MicroRNAs are crucial regulators in cell reprogramming, expanding our understanding of cellular plasticity.
- The strategic use of miRNAs can advance regenerative medicine and cell-based therapies.
- Further research into miRNA-mediated reprogramming is essential for future therapeutic applications.
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