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Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
Published on: April 21, 2016
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Complementary metal oxide semiconductor-compatible silicon nanowire biofield-effect transistors as affinity
Xuexin Duan1, Nitin K Rajan, Mohammad Hadi Izadi
1State Key Laboratory of Precision Measuring Technology & Instruments, Tianjin University, Tianjin 300072, China.
Nanomedicine (London, England)
|October 26, 2013
Summary
Silicon nanowire field-effect transistors (Si-NW FETs) are advancing as affinity biosensors. These devices offer real-time, label-free detection and can quantify biomolecular binding kinetics for nanomedicine and point-of-care applications.
Area of Science:
- Nanotechnology
- Biosensing
- Biophysics
Background:
- Affinity biosensors convert biochemical events into signals using biorecognition elements and transducers.
- Silicon nanowire field-effect transistors (Si-NW FETs) offer sensitive, real-time, label-free detection of biomolecules.
- Existing research often prioritizes detection limits over detailed binding parameter analysis.
Purpose of the Study:
- To review recent advancements in using Si-NW FETs for bioaffinity measurements.
- To highlight methods for quantifying biomolecular binding affinities and kinetics.
- To discuss challenges and solutions in Si-NW FET biosensor development.
Main Methods:
- Utilizing Si-NW FETs as affinity biosensors for real-time biomolecular interaction analysis.
- Investigating sensor calibration, regeneration, and surface modification techniques.
- Addressing issues like charge screening, reference electrode integration, and non-specific binding.
Main Results:
- Si-NW FETs are demonstrated to quantify biomolecular binding affinities and kinetics.
- Advances enable more comprehensive analysis of biomolecular interactions beyond detection limits.
- Various approaches are being developed to overcome key sensor challenges.
Conclusions:
- Si-NW FETs show significant promise as advanced affinity biosensors.
- These sensors are crucial for nanomedicine and potential point-of-care diagnostics.
- Further development will enhance their reliability and applicability in biological and medical fields.
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