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Updated: May 6, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
C-H nitrogenation and oxygenation by ruthenium catalysis
Vedhagiri S Thirunavukkarasu1, Sergei I Kozhushkov, Lutz Ackermann
1Institut fuer Organische und Biomolekulare Chemie, Georg-August-Universitaet, Tammannstrasse 2, 37077 Goettingen, Germany. lutz.ackermann@chemie.uni-goettingen.de.
Abstract:
Remarkable recent progress has been accomplished in direct C-H functionalizations for the formation of C-N and C-O bonds through the use of readily accessible ruthenium catalysts. Particularly, ruthenium(II) complexes allowed for challenging direct C(sp(2))-H hydroxylation of arenes. These catalysts set the stage for step-economical C-H functionalization with electron-rich as well as electron-deficient (hetero)arenes and, therefore, provided versatile access to diversely decorated phenols. While a number of synthetically useful protocols for ruthenium-catalyzed C(sp(3))-H bond nitrogenation have been elaborated, the analogous transformations of more stable C(sp(2))-H bonds were very recently achieved.
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