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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Hyperpolarized H2 O MR angiography.

Jan H Ardenkjaer-Larsen¹, Christoffer Laustsen, Sean Bowen

¹Technical University of Denmark, Kgs Lyngby, Denmark; Danish Research Center for Magnetic Resonance, Hvidovre Hospital, Hvidovre, Denmark; GE Healthcare, Broendby, Denmark.

Magnetic Resonance in Medicine

|November 19, 2013

Summary

This summary is machine-generated.

Dynamic nuclear polarization successfully hyperpolarized water protons, achieving a 77-fold signal enhancement. This breakthrough enables rapid, high-contrast Magnetic Resonance Angiography (MRA) imaging using hyperpolarized water as a contrast agent.

Keywords:

angiography dynamic nuclear polarization hyperpolarization

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Area of Science:

Magnetic Resonance Imaging
Nuclear Physics
Medical Imaging

Background:

Dynamic Nuclear Polarization (DNP) is a technique to enhance nuclear magnetic resonance (NMR) signals.
Hyperpolarization of water is crucial for improving MRI sensitivity.
Angiographic applications require rapid imaging with high signal-to-noise ratios.

Purpose of the Study:

To demonstrate the capability of dissolution-dynamic nuclear polarization (d-DNP) for hyperpolarizing water protons.
To show that hyperpolarized water bolus injection signals can be utilized in angiographic imaging.
To establish a novel contrast agent for enhanced MRA.

Main Methods:

Water/glycerol mixtures were hyperpolarized using d-DNP.
Polarized solution was dissolved in D2O for subsequent use.
Magnetic Resonance Angiography (MRA) was performed with the hyperpolarized agent.

Main Results:

A 77-fold enhancement of the water (1)H signal was achieved at 4.7 Tesla.
A polarization level of 3.5% for (1)H in D2O was obtained.
A longitudinal relaxation time (T1) exceeding 20 seconds was measured.

Conclusions:

Hyperpolarized water serves as a novel contrast agent for MRA.
This method allows for high contrast-to-noise MRA images.
Imaging can be completed in a fraction of a second, improving diagnostic speed.