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A new HLA-A*01 allele - A*01:139
J Street1, J Johnson, J Pepperall
1Welsh Transplantation and Immunogenetics Laboratory, Welsh Blood Service, Pontyclun, Wales, UK.
Tissue Antigens
|November 30, 2013
Summary
A novel Human Leukocyte Antigen (HLA) allele, HLA-A*01:139, has been identified. This new HLA allele differs from HLA-A*01:01:01:01 by a single nucleotide change, leading to an amino acid alteration.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- Human Leukocyte Antigen (HLA) genes are crucial for immune response.
- Polymorphisms in HLA genes contribute to diverse immune capabilities.
Purpose of the Study:
- To report the discovery and characterization of a new HLA-A allele.
Main Methods:
- Nucleotide sequencing of the HLA-A gene.
- Comparison with existing HLA allele databases.
Main Results:
- A novel HLA allele, designated HLA-A*01:139, was identified.
- This allele differs from HLA-A*01:01:01:01 by a single nucleotide substitution at position 383 (G>C).
- The nucleotide change results in an amino acid substitution from glycine to alanine at position 104.
Conclusions:
- The identification of HLA-A*01:139 expands the known HLA-A allele repertoire.
- This finding contributes to the understanding of HLA polymorphism and its implications for immune studies.
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