Related Experiment Video
Updated: May 5, 2026
Optimization of Radiochemical Reactions using Droplet Arrays
Published on: February 12, 2021
Microfluidics for synthesis of peptide-based PET tracers
Yang Liu1, Mei Tian, Hong Zhang
1Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Zhejiang University Medical PET Center, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China.
Microfluidic radiolabeling simplifies the complex synthesis of peptide-based positron emission tomography (PET) tracers. This technology offers a promising solution for large-scale clinical studies in cancer imaging.
Area of Science:
- Nuclear Medicine
- Radiochemistry
- Biomedical Engineering
Background:
- Positron emission tomography (PET) enables noninvasive physiological parameter acquisition using PET tracers.
- Radiolabeled peptides are valuable PET tracers for cancer receptor imaging due to high affinity and specificity.
- Current radiochemistry procedures for peptide-based PET tracers are complex, hindering large-scale clinical application.
Purpose of the Study:
- To describe microfluidic radiolabeling technology.
- To summarize and discuss the application of microfluidics in synthesizing peptide-based PET tracers.
- To highlight the need for simplified radiolabeling technologies for PET tracer production.
Main Methods:
- Review of microfluidic and lab-on-a-chip (LOC) technologies in organic chemistry.
- Application of microfluidic systems for the synthesis of peptide-based PET tracers.
- Discussion of simplified synthesis and purification procedures enabled by microfluidics.
Main Results:
- Microfluidics offers a powerful tool to address the complexity of PET tracer synthesis.
- Lab-on-a-chip technology can significantly aid PET chemistry.
- Microfluidic radiolabeling streamlines the production of peptide-based PET tracers.
Conclusions:
- Microfluidic radiolabeling technology is a crucial advancement for PET tracer development.
- This technology has the potential to overcome challenges in large-scale clinical studies.
- Further development and application of microfluidics will enhance cancer imaging capabilities.
![Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F55537.jpg&w=3840&q=50)