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Updated: May 5, 2026
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Expression profile of inflammatory breast cancer
M Yu Shkurnikov1, I N Nechaev, N A Khaustova
1Institue of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences; BioClinicum Laboratory; BioClinicum Research and Technological Center, Moscow; Moscow Municipal Oncological Hospital No. 62, Department of Health of Moscow, Moscow Region, Istra; P. A. Hertsen Moscow Cancer Institute, Ministry of Health and Social Development of the Russian Federation, Russia. mshkurnikov@gmail.com.
Abstract:
Inflammatory breast cancer is characterized by high malignancy, early and rapid lymphogenic and hematogenic metastasizing, and high mortality. The diagnosis of this form of cancer is based fully on the clinical criteria. Whole transcriptome analysis of tumor tissue specimens from patients with inflammatory breast cancer detected 137 differentially expressed mRNA (17 genes with low expression and 120 with high expression). Genes involved in the organization of inflammatory process, chemotaxis, and transcription regulation were active in the process of pathogenesis of inflammatory breast cancer.
