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Related Concept Videos

Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Related Experiment Video

Updated: May 4, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

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Lung function in African infants: a pilot study.

D M Gray1, L Willemse, A Alberts

  • 1Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.

Pediatric Pulmonology
|December 17, 2013
PubMed
Summary
This summary is machine-generated.

Infant lung function testing is feasible in South Africa, providing crucial data for respiratory health in low-income countries. This pilot study shows successful implementation of tidal breathing, exhaled nitric oxide, and multiple breath washout measures.

Keywords:
South Africapaediatricrespiratory function test

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Area of Science:

  • Pediatric Pulmonology
  • Global Health
  • Respiratory Medicine

Background:

  • Childhood respiratory illnesses pose a significant burden in low and middle-income countries (LMICs).
  • Infant lung function (ILF) testing can reveal insights into lung development and disease susceptibility.
  • ILF testing has been largely inaccessible in LMICs, despite the high prevalence of respiratory diseases.

Purpose of the Study:

  • To pilot the implementation and assess the feasibility of infant lung function testing in a semi-rural South African setting.
  • To evaluate the effectiveness of established ILF testing protocols in a resource-limited environment.

Main Methods:

  • Established ILF testing at a community hospital, utilizing unsedated infants during sleep.
  • Employed measures including tidal breathing (TBFVL), exhaled nitric oxide (eNO), and sulfur hexafluoride multiple breath washout (MBW).
  • Utilized an ultrasonic flow meter and chemoluminescent NO analyzer for precise measurements.

Main Results:

  • Successfully tested 20 infants (mean age 7.7 weeks), including preterm and diverse ethnic groups.
  • Achieved high success rates: 95% for TBFVL and eNO, 90% for MBW.
  • Obtained lung function values comparable to normative data from high-income countries, with low intra-subject variability.

Conclusions:

  • Demonstrated the feasibility of conducting unsedated infant lung function tests (tidal breathing, MBW, eNO) in a semi-rural African setting.
  • ILF testing in this LMIC context yielded results comparable to those from high-income countries.
  • This pilot study supports the expansion of ILF testing to improve respiratory health management in underserved populations.