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[Preface for special issue on synthetic biology (2013)]
1School of Life Sciences, Tsinghua University, Beijing 100084, China. chengq@tsinghua.edu.cn
Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|December 25, 2013
Summary
Synthetic biology advances rapidly, enhancing gene editing, genome engineering, and microbial chassis development. Applications include complex natural product biosynthesis and bio-based chemical production.
Area of Science:
- Synthetic biology
- Molecular biology
- Metabolic engineering
Context:
- Rapid global development in synthetic biology technologies and applications.
- Focus on advancements in microbial systems and genetic manipulation.
- Exploration of novel biological chassis and cost-estimating criteria.
Purpose:
- To review recent progress in synthetic biology technologies.
- To highlight key applications of synthetic biology.
- To discuss emerging areas like protein budgeting and genome minimization.
Summary:
- Covers markerless gene knockout, gene synthesis, microbial genome reduction, and minimization strategies.
- Discusses photosynthetic cyanobacteria and solventogenic clostridia as chassis.
- Includes applications in natural product biosynthesis, S. cerevisiae engineering, and bio-based chemical production.
Impact:
- Enables precise genetic modification in diverse microbial systems.
- Facilitates the development of novel bio-based chemicals and products.
- Provides a framework for understanding and optimizing synthetic biological designs.
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