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Updated: May 4, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Solvatochromic fluorescent 2-substituted 3-ethynyl quinoxalines: four-component synthesis, photophysical properties,
Charlotte F Gers1, Jan Nordmann, Ceyda Kumru
1Institut für Organische Chemie und Makromolekulare Chemie and ‡Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine Universität Düsseldorf , Universitätstrasse 1, D-40225 Düsseldorf, Germany.
Abstract:
2-Substituted 3-ethynylquinoxalines can be rapidly synthesized in generally excellent yields by a consecutive four-component synthesis starting from electron-rich π-nucleophiles, oxalyl chloride, terminal alkynes, and 1,2-diaminoarenes. The title compounds are highly fluorescent with a pronounced emission solvatochromism. The photophysical properties and electronic structure were additionally corroborated by computations on the DFT level of theory.
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