Macrophages in multiple myeloma
Domenico Ribatti1, Michele Moschetta2, Angelo Vacca2
1Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy; National Cancer Institute "Giovanni Paolo II", Bari, Italy.
Abstract:
Tumor associated macrophages (TAMs) are a rich source of pro-angiogenic cytokines and growth factors, and a relationship between the TAMs content, the rate of tumor growth and the extent of vascularization has been shown in several tumors. In this article, we have summarized the literature and our data concerning the involvement of TAMs in angiogenesis occurring in multiple myeloma. Finally, therapeutic aspects concerning the potential role of molecules which inhibit macrophage recruitment in the tumor side are also discussed.
Insights
Tumor associated macrophages (TAMs) promote tumor growth and vascularization by releasing growth factors. Inhibiting macrophage recruitment may offer a new therapeutic strategy for multiple myeloma.
Area of Science:
- Oncology
- Immunology
- Hematology
Background:
- Tumor-associated macrophages (TAMs) are key players in tumor microenvironments.
- TAMs secrete pro-angiogenic factors that support tumor growth and vascularization.
- Previous studies show a link between TAMs, tumor growth rate, and vascularization in various cancers.
Purpose of the Study:
- To summarize existing literature and present new data on the role of TAMs in multiple myeloma angiogenesis.
- To discuss potential therapeutic strategies targeting macrophage recruitment in multiple myeloma.
Main Methods:
- Literature review of TAMs and angiogenesis in multiple myeloma.
- Analysis of experimental data concerning TAMs in multiple myeloma models.
- Discussion of therapeutic agents targeting macrophage recruitment.
Main Results:
- TAMs are a significant source of pro-angiogenic cytokines and growth factors in multiple myeloma.
- A correlation exists between TAM content, tumor growth rate, and vascularization in multiple myeloma.
- Inhibiting macrophage recruitment presents a potential therapeutic avenue.
Conclusions:
- TAMs play a crucial role in promoting angiogenesis and tumor progression in multiple myeloma.
- Targeting macrophage recruitment offers a promising therapeutic strategy for multiple myeloma treatment.
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