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Updated: May 4, 2026

Quantitative, Real-time Analysis of Base Excision Repair Activity in Cell Lysates Utilizing Lesion-specific Molecular Beacons
Published on: August 6, 2012
Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences
Ki Tae Kim1, Rakesh N Veedu, Young Jun Seo
1Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, South Korea. bhkim@postech.ac.kr.
Abstract:
We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of their (Py)U units.
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