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Vascular calcification in long-term kidney transplantation
Kotcharat Vipattawat1, Chagriya Kitiyakara, Bunyong Phakdeekitcharoen
1Division of Nephrology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Nephrology (Carlton, Vic.)
|January 23, 2014
Summary
Kidney transplantation does not prevent vascular calcification (VC) progression. Long-term kidney transplant recipients showed more severe VC than chronic kidney disease (CKD) patients, influenced by dialysis history.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Transplantation
Background:
- Vascular calcification (VC) is prevalent in chronic kidney disease (CKD) due to risk factors like diabetes mellitus (DM) and hypertension.
- Kidney transplantation (KT) aims to improve kidney function and mineral metabolism, but its long-term effect on VC is unclear.
Purpose of the Study:
- To investigate the long-term impact of kidney transplantation on vascular calcification (VC).
- To compare VC severity in long-term kidney transplant recipients versus patients with advanced CKD.
Main Methods:
- The study compared VC in 132 kidney transplant (KT) recipients (transplanted >1 year) with 129 CKD stage 5-5D patients on a waiting list.
- VC severity was assessed and compared between the two groups, controlling for demographic and clinical factors.
Main Results:
- No significant difference in VC prevalence between KT recipients (54.5%) and CKD patients (62.8%).
- KT recipients with calcification showed a more severe degree of VC (P=0.01).
- VC severity increased with time post-transplant, particularly after 5 years, and was influenced by prior dialysis vintage.
Conclusions:
- Long-term kidney transplant recipients exhibit more severe vascular calcification than comparable CKD patients.
- The degree of VC is associated with longer transplant duration and past dialysis exposure.
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