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[Correlation of VEGF expression with microvessel and microlymphatic density in sinonasal squamous cell carcinoma]
Zhi Tang1, Jin Sun2, Jiqun Wang3
1Department of Otolaryngology, First People's Hospital of Shunde City Affiliated to Southern Medical University, Shunde 528300, China. damaodoctor@126.com
Objective:
To study the expression of VEGF in sinonasal squamous cell carcinoma and its correlations with microvessel density (MVD), microlymphatic vessel density (MLVD).
Method:
The expression of VEGF, MVD and MLVD in 41 cases of sinonasal squamous cell carcinoma were detected by immunohistochemical technique.
Result:
In the sinonasal squamous cell carcinoma, the positive rate of VEGF was 82.9% (34/41). The over expression of VEGF was related with tumor invasion, histological grading and lymphatic metastasis (P < 0.05). The MVD of cases with positive VEGF expression was significantly higher than those without VEGF expression (P < 0.05), but was not statistical difference in MLVD (P > 0.05).
Conclusion:
VEGF may participate in the metastasis of sinonasal squamous cell carcinoma through promoting vascularization in the tumors, but not promoting MLVD.
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