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Rota virus Diarrhea in Hospitalized Children

Muhammad Irfan Habib1, Sayyeda Ghazala Kazi2, Khalid Mehmood Ahmed Khan1

  • 1Department of Paediatrics, National Institute of Child Health, Karachi.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|February 5, 2014
PubMed

Insights

Rotavirus is a common cause of diarrhea in children under three years old. This study highlights the need for rotavirus vaccination in national immunization programs to reduce the disease burden.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Rotavirus is a leading cause of severe diarrheal disease in infants and young children globally.
  • Understanding the local epidemiology of rotavirus gastroenteritis is crucial for public health interventions.

Purpose of the Study:

  • To determine the incidence and clinical characteristics of rotavirus diarrhea in children presenting at a tertiary care hospital.
  • To provide data supporting the integration of rotavirus vaccination into national immunization schedules.

Main Methods:

  • A cross-sectional, observational study was conducted involving 300 children aged 1 month to 5 years with diarrhea.
  • Stool samples were analyzed for rotavirus using enzyme-linked immunoassay (ELISA).
  • Exclusion criteria included bloody diarrhea and nosocomial gastroenteritis.

Main Results:

  • Rotavirus was detected in 188 (63%) of the 300 children studied.
  • The highest prevalence was observed in children aged 7-12 months (18.08%).
  • Over 80% of positive cases were in children under 3 years old, with fever and vomiting being common symptoms.

Conclusions:

  • Rotavirus is a significant pathogen responsible for a substantial proportion of diarrhea cases in young children in this region.
  • The findings underscore the importance of rotavirus vaccination to mitigate the impact of this disease.
Abstract

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