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Updated: May 2, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
Published on: September 20, 2021
Orbital apex syndrome secondary to herpes zoster virus infection
Alexia Merino-Iglesias1, Javier Antonio Montero, Maria Calabuig-Goena
1Department of Ophthalmology, Pio del Rio Hortega University Hospital, Valladolid, Valladolid, Spain.
Abstract:
A male patient with herpes zoster ophthalmicus (HZO) presented with left exophthalmos, external and internal ophthalmoplegia and decreased visual acuity. A CT scan revealed myositis without significant compression of the optic nerve. Intravenous acyclovir and oral steroids were started with improvement of the symptoms and eventual complete recovery.Orbital apex syndrome is a rare complication of HZO. Multiple pathogenic mechanisms are involved, including a direct cytopathic effect of the virus as in the present case. Early diagnosis and therapy may lead to complete recovery of visual function.
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