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Published on: August 13, 2019
De novo bone regeneration in human extraction sites using recombinant human bone morphogenetic protein-2/ACS: a
Stephen C Wallace1, Michael A Pikos, Hari Prasad
1*Private Practice, Periodontics, Wilmington, NC. †Private Practice, Oral Maxillofacial Surgery, Palm Harbor, FL; Director, Pikos Implant Institute, Spring Hill, FL. ‡Senior Research Scientist, Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN.
Introduction:
To preserve alveolar bone after extractions, it is important to graft socket sites to prevent bone loss from repair and remodeling.
Objective:
The objective of this case series was to assess the clinical, densitometric, and histomorphometric results from extraction sockets treated with recombinant human bone morphogenetic protein (rhBMP-2/ACS).
Study Design:
After extraction and socket debridement, INFUSE (rhBMP-2) on absorbable sponges was placed over each socket. After 4 months, 3-dimensional cone-beam computerized tomographic (CT) scans were taken. Trephined bone cores were taken as the first step in the implant site osteotomy and submitted for histomorphometric analysis.
Results:
Histomorphometric analysis showed a mean of 49.6% vital bone with a SD of 10.8%. CT scans showed mean density of 510.6 Hounsfield units.
Conclusions:
Use of INFUSE in socket preservation surgery results in adequate de novo bone formation to support ideal implant placement after 4 months.
