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Oral solid self-emulsifying formulations: a patent review.
Bapurao Tarate, Rahul Chavan, Arvind K Bansal1
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar (Mohali), Punjab-160 062, India. akbansal@niper.ac.in.
Recent Patents on Drug Delivery & Formulation
|March 18, 2014
Summary
This review explores patent literature on oral solid self-emulsifying drug delivery systems. It highlights advancements in formulations and manufacturing techniques to improve oral drug bioavailability.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Self-emulsifying compositions are lipid-based drug delivery systems offering significant advantages.
- These systems, classified as Type I-IV or solid, semi-solid, and liquid, utilize various excipients.
- Numerous patents and some commercial products exist for self-emulsifying compositions.
Purpose of the Study:
- To review patent literature focusing on oral solid self-emulsifying formulations.
- To provide insights into recent developments and manufacturing techniques.
- To guide the enhancement of oral bioavailability using this drug delivery platform.
Main Methods:
- Comprehensive review of patent literature concerning oral solid self-emulsifying formulations.
- Analysis of different formulation types including conventional, granules, pellets, tablets, supersaturable, controlled release, eutectic-based, and positively charged systems.
- Examination of various components beyond oils, surfactants, and cosurfactants, such as binders, polymers, and stabilizing agents.
Main Results:
- Identification of diverse advancements in oral solid self-emulsifying formulations through patent analysis.
- Overview of manufacturing techniques applicable to these advanced formulations.
- Highlighting the inclusion of a wide range of excipients beyond basic components.
Conclusions:
- Patent literature reveals significant progress in oral solid self-emulsifying drug delivery systems.
- These systems offer a promising platform for enhancing oral bioavailability of drugs.
- The review provides valuable guidelines for future development and innovation in this field.
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