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A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence

Rakesh H Vekariya1, Ruzhang Liu, Jeffrey Aubé

  • 1Department of Medicinal Chemistry, University of Kansas , Lawrence, Kansas 66045, United States.

Organic Letters
|March 19, 2014
PubMed
Summary

This study demonstrates controlling triazole formation using intramolecular Huisgen cycloadditions. Reaction conditions, whether thermal or copper-catalyzed, dictate whether substituted triazoles or macrocyclic products are formed.

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