Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Achalasia01:27

Esophageal Achalasia

45
Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide...
45
Acute Pharyngitis01:30

Acute Pharyngitis

6.6K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
6.6K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.9K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.9K
Chronic Pharyngitis01:23

Chronic Pharyngitis

16.7K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
16.7K
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

2.3K
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
2.3K
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

52
The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
52

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal Predictors of Dental Caries, Periodontal Disease and Oral Health Quality of Life in People with HIV on ART: The OHART study.

Research square·2026
Same author

Heterogeneous tumor microenvironment - A hallmark of ameloblastoma invasive phenotype.

Cancer letters·2026
Same author

Race is a Contributing Factor to Clinico-Pathological Characteristics of Ameloblastoma at a Multi-Network Academic Hospital System.

Journal of racial and ethnic health disparities·2026
Same author

Exploratory Advanced Radiotherapies for Ameloblastoma and Ameloblastic Carcinoma-A Concise Review.

Oral diseases·2025
Same author

Diagnostic and Therapeutic Approaches to Jaw Osteoradionecrosis.

Diagnostics (Basel, Switzerland)·2024
Same author

Differentially expressed extracellular matrix genes functionally separate ameloblastoma from odontogenic keratocyst.

BMC oral health·2024
Same journal

Contemporary Oral and Maxillofacial Trauma: A Dental Perspective.

Dental clinics of North America·2026
Same journal

The Expanding Role of Virtual Surgical Planning in Maxillofacial Trauma Management.

Dental clinics of North America·2026
Same journal

Revision Surgery for Occlusal Correction in Facial Trauma.

Dental clinics of North America·2026
Same journal

Mandibular Condylar Fractures and Occlusal Management.

Dental clinics of North America·2026
Same journal

Occlusion Management in Facial Trauma: A Literature Review.

Dental clinics of North America·2026
Same journal

Dental Implants in Rehabilitation of Patients with Facial Trauma: a Review of Most Current Practices.

Dental clinics of North America·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
07:27

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

11.3K

Recurrent aphthous stomatitis.

Sunday O Akintoye1, Martin S Greenberg1

  • 1Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, 240 South 40th Street, Philadelphia, PA 19104, USA.

Dental Clinics of North America
|March 25, 2014
PubMed
Summary
This summary is machine-generated.

Recurrent aphthous stomatitis (RAS) is a common oral condition. Its causes are unknown, but treatments aim to reduce pain, heal ulcers, and prevent future outbreaks.

Keywords:
AphthousBehçet diseaseCrohn diseaseImmunologicNutritional deficiencyPsychological stressSystemic therapyTopical therapy

More Related Videos

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
05:26

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

2.5K
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

9.0K

Related Experiment Videos

Last Updated: May 1, 2026

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
07:27

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

11.3K
Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
05:26

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

2.5K
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

9.0K

Area of Science:

  • Oral Medicine
  • Immunodermatology
  • Pathology

Background:

  • Recurrent aphthous stomatitis (RAS) is the most frequent ulcerative condition impacting the oral mucosa.
  • While typically seen in healthy individuals, RAS presents atypically in immunocompromised patients.
  • The precise etiology of RAS remains elusive, with numerous factors implicated.

Purpose of the Study:

  • To review the current understanding of recurrent aphthous stomatitis (RAS).
  • To explore the diverse proposed etiologies, including local, systemic, immunologic, genetic, allergic, nutritional, and microbial factors.
  • To outline the principles of clinical management and therapeutic goals for RAS.

Main Methods:

  • Literature review of studies on recurrent aphthous stomatitis.
  • Analysis of proposed etiological factors.
  • Synthesis of current clinical management strategies and therapeutic objectives.

Main Results:

  • RAS is a prevalent oral ulcerative disease with unknown etiology.
  • Multiple factors are suggested as causative agents for RAS.
  • Therapeutic strategies focus on symptom severity, lesion characteristics, and recurrence rates.

Conclusions:

  • Effective management of RAS involves tailored topical and systemic therapies.
  • Treatment aims to alleviate pain, accelerate healing, and reduce the frequency of RAS episodes.
  • Further research is needed to elucidate the definitive causes of recurrent aphthous stomatitis.