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Updated: May 1, 2026
Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
Published on: December 11, 2020
Oxidative stress regulation by DJ-1 in the retinal pigment epithelium
Vera L Bonilha1, Mary E Rayborn, Xiaoping Yang
1Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, The Cole Eye Institute, i31, 9500 Euclid Avenue, 44195, Cleveland, OH, USA, bonilhav@ccf.org.
Abstract:
DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson's Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.
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