[Fibrin glue and tricalcium phosphate implants in middle ear surgery. An animal experiment study]

Tricalcium phosphate (TCP) with and without heterologous fibrin glue has been used for obliteration of the mastoid cavity in middle ear surgery. The use of TCP with a homologous fibrin glue has not been described so far. Obliteration of 22 epitympanic and 51 femoral defects in rabbits by means of TCP-granulates without and with homologous fibrin glue was performed in 18 animals. Follow-up was for 2 weeks to 6 months. Histological osteo-integration was studied microscopically. Fibrin glue induces the development of soft tissue impeding osseous integration of the calcium phosphate for at least 6 weeks.