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Updated: May 1, 2026

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis
Published on: December 18, 2019
Emerging genetic basis of osteochondritis dissecans
J Tyler Bates1, John C Jacobs2, Kevin G Shea3
1Department of Biological Sciences, Biomolecular Research Center, Musculoskeletal Research Institute, Boise State University, 1910 University Drive, Boise, ID 83725, USA.
Abstract:
Genome-wide association studies (GWAS) provide an unbiased approach in the identification of genes that increase the risk for osteochondritis dissecans (OCD). Recent GWAS in humans, horses, and pigs are reviewed and genes identified. The identified genes tended to cluster with respect to function and biologic processes. GWAS in humans are a critical next step in the effort to provide a better understanding of the causes of OCD, which will, in turn, allow preventive strategies for treatment of adolescents and young adults who are at risk for the development of degenerative joint disease due to the effects of OCD.
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