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Tissue factor and tissue factor pathway inhibitor in chronically inflamed gallbladder mucosa
Jacek Liczko1, Tomasz Stawski2, Małgorzata Zaba1
1Department of Histology and Embryology, Medical University of Silesia in Katowice, Jordana Street 19, 41-808 Zabrze, Poland.
Biomed Research International
|April 10, 2014
Summary
Tissue factor (TF) and TFPI expression were analyzed in chronic cholecystitis. Findings suggest a procoagulant state in gallbladder inflammation, potentially contributing to disease development.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Chronic cholecystitis involves significant gallbladder mucosal inflammation.
- Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) play roles in coagulation and inflammation.
Purpose of the Study:
- To investigate the expression of TF and TFPI in relation to the severity of inflammation in chronic cholecystitis.
- To determine if TF and TFPI expression correlates with inflammatory cell infiltration.
Main Methods:
- Prospective study of 54 chronic calculous cholecystitis patients and 16 controls.
- Immunohistochemistry used to assess TF and TFPI expression with monoclonal antibodies.
- Inflammatory infiltration quantified by CD3 (lymphocytes) and CD68 (macrophages) positive cell counts.
Main Results:
- Significant differences in TF and TFPI expression were observed between cholecystitis and control groups.
- Weak TFPI expression noted in capillary endothelial cells of the cholecystitis group.
- Higher CD3 and CD68 positive cell counts in cholecystitis (18.6±12.2 and 29.7±13.9) vs. controls (3.1±1.9 and 8.8±3.9, P < 0.001).
Conclusions:
- A tissue procoagulant state is present in chronic cholecystitis.
- This procoagulant state may be involved in the etiopathogenesis of the disease.
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